Clinical Genomics Scientist, Oncology

Help drive somatic mutation variant interpretation and reporting. The company recently launched two oncology liquid biopsy products : Northstar Select™ and Northstar Response™ for late-stage solid-tumor cancer patients. As a member of the oncology clinical genomics team, you are responsible for helping with day-to-day commercial reporting operations, including variant interpretation and report drafting. Work closely with the medical team, you will develop interpretation and reporting policies based on the latest publications and guidelines, and help scale-up our ever growing reporting needs. Perform somatic-based variant interpretation, diving into the literature and databases to classify variants and match treatments for reporting, performing verification as required with BAM file analysis. Carefully draft reports for each requisition primarily using in-house reporting API, working closely with the engineering and QA teams on reporting, and the laboratory directors on report language. Work closely with lab directors, R&D, medical, and other related functions to develop and modify the somatic interpretation SOPs in accordance with ACMG/AMP guidelines, and the latest published literature. Contribute to curation of gene-level content such as domain and critical residue curation. Serve as a subject matter expert in consulting with the medical science liaison team, and presenting in molecular tumor boards to facilitate knowledge sharing. Work closely with the R&D team to help with somatic oncology based projects, providing expertise on variant interpretation, biological pathways/mechanisms, and other gene/variant-level reviews and analyses.