Source Job

$250,000–$350,000/yr
US

  • Co-direct the research program in partnership with the founder to shape scientific vision and technical execution.
  • Develop RL feedback loops translating high-throughput biological measurements into reward signals for biological language models.
  • Perform hands-on engineering including architecting model training infrastructure and building, running, and debugging models.

Machine Learning Reinforcement Learning Transformers

20 jobs similar to Principal AI Scientist

Jobs ranked by similarity.

$280,500–$330,000/yr
North America

  • Define and evolve the standards, architecture patterns, and tooling choices for AI adoption across the codebase.
  • Own execution of the multi-milestone AI-Native Transformation roadmap in partnership with squad leads.
  • Set policy and technical controls for safe AI adoption, balancing speed with security and quality.

Change.org is the world's largest platform for democracy, used by over 100 million people annually. They are expanding a talented team focused on building healthier democracies globally.

$120,000–$180,000/yr

  • Contribute to technical approach for evaluating AI agents' reasoning through biological function, recovering and interpreting experimental evidence.
  • Build ground-truth benchmark datasets from real discovery programs to test agents' quantitative reasoning capabilities.
  • Use expertise in functional biology assays and computational modeling to define metrics for agent capability in biological sequences and structures.

LatchBio builds intelligent, high-performance agents for biological data analysis, empowering over 5,000 scientists across 150+ R&D labs. They work at the frontier of artificial intelligence in biology.

North America Unlimited PTO 12w maternity 8w paternity

  • Lead state-of-the-art research and development in AI/ML, advanced statistical modeling, and applied mathematics to solve security problems.
  • Develop novel AI workflows and models to address Ent's security challenges, incorporating and advancing current SOTA approaches.
  • Collaborate with the team to invent frameworks and theoretical grounding while thinking outside the box to combine multiple techniques.

Ent is an intent-aware workspace security platform that secures human and AI-driven work by understanding intent and intervening at the moment of risk. Founded by former RiskIQ co-founders, backed by leading VCs, and in production with Global 2000 customers, the company values a customer-first, humble, and urgent culture.

$154,084–$263,131/yr
US Unlimited PTO

  • Lead development of Dyno’s external-facing AI platforms (e.g., design.dynotx.com)
  • Develop field-relevant benchmarks for agentic tasks in biological design
  • Build and improve AI-driven workflows that integrate models, data systems, and experimental feedback

Dyno Therapeutics is a biotech company that develops AI-driven genetic technologies to transform patient lives. They are a high-energy, high-impact team of world-class scientists and engineers working at the intersection of AI and genetic medicine.

$200,000–$300,000/yr
US Unlimited PTO

  • Design, build, and own agentic systems that produce client-ready financial deliverables from data ingestion to polished output.
  • Build evaluation and quality systems for generated deliverables, including deterministic checks and model-judged review.
  • Turn proprietary data into evidence-backed insight by building pipelines that discover and verify patterns.

Farsight is the agentic AI platform for financial services, helping investment banks and private equity firms automate nuanced workflows. The team comes from leading financial institutions and tech companies, focusing on hiring the best to become the best.

$180,000–$200,000/yr
US

  • Design and deploy scalable AI and machine learning architectures using modern frameworks like LLMs and cloud platforms.
  • Develop, train, and optimize AI models, data pipelines, and AI-powered services with intelligent agents.
  • Collaborate with technical and business leaders to define AI strategy and translate business objectives into technical solutions.

They build advanced AI-powered systems for automation and business transformation. They offer a remote-first environment with a culture focused on integrity, respect, innovation, and continuous improvement.

$320,000–$370,000/yr
US

  • Lead the vision, strategy, and execution of next-generation AI agent technologies within a high-impact cybersecurity environment.
  • Drive innovation through scalable agentic systems that automate complex workflows and enhance operational capabilities.
  • Collaborate across engineering, data science, and operational teams to shape AI-driven transformation and measurable outcomes.

Our partner is a cybersecurity company specializing in AI-driven threat research and intelligent automation. They operate in a fast-paced, innovation-focused environment with a remote-first culture.

$200,000–$300,000/yr
US 5w PTO

  • Define and own the company's AI transformation strategy, ensuring alignment with business goals.
  • Manage AI budgets, governance, and cross-functional initiatives to drive adoption across the organization.
  • Act as an AI champion, translating complex concepts for non-technical audiences and fostering excitement.

ButterflyMX provides a single platform to automate property access, operations, and security. The company has a distributed, primarily remote workforce with a culture focused on collaboration, innovation, and customer delight.

US

  • Design and manage Cloudflare's Sales Compensation Plans across all customer-facing teams, architecting new metrics for AI-native business models.
  • Lead C-level discussions with executives on compensation philosophy, serving as design authority on the Executive Compensation Steering Committee.
  • Build an AI-native compensation design framework and application for accelerated plan modeling, scenario simulation, and predictive analytics.

Cloudflare runs one of the world’s largest networks, powering millions of websites and Internet properties for customers ranging from individual bloggers to Fortune 500 companies. Named to Entrepreneur Magazine’s Top Company Cultures list, Cloudflare values builders who spot problems and use AI to create solutions, fostering a culture of iteration and collaboration.

Global

  • Evaluate LLM architecture logic for technical accuracy and audit ML code and notebooks for efficiency.
  • Refine RLHF frameworks to align models with human intent and analyze model reasoning in complex chain-of-thought prompts.
  • Benchmark performance by conducting comparative testing between model outputs based on technical metrics.

Prolific connects researchers with a global pool of participants for collecting high-quality human data to train AI models. With over 35,000 users, they focus on ethical data gathering to advance AI capabilities.

$160,000–$210,000/yr
US Unlimited PTO

  • Define and lead the enterprise AI innovation strategy aligned with business priorities and customer outcomes.
  • Identify and prioritize high-impact AI use cases to drive growth, efficiency, and competitive differentiation.
  • Build and manage external AI ecosystems, including partnerships with startups and research institutions.

$150,000–$185,000/yr
US

  • Lead agentic workshops with customer process owners to design AI-driven manufacturing workflows.
  • Architect integrated enterprise solutions including ERP, PLM, and sourcing tools, prototyping on-site.
  • Own the end-to-end build and go-live, pairing with offshore engineering teams and driving UAT.

QAD provides adaptive, cloud-based enterprise software solutions for global manufacturing companies. It is a virtual-first company with a collaborative culture focused on growth, innovation, and well-being.

US

  • Design and implement AI systems for complex workflows, including multi-step reasoning and decision making.
  • Lead systematic experimentation and evaluation of agentic systems.
  • Finetune and adapt small and medium-sized foundation models for enterprise workloads.

Uniphore is a B2B AI-native company that builds a multimodal AI platform for enterprises, combining Generative AI, Knowledge AI, and automation. It is one of the largest companies in its space, with a culture focused on innovation and customer success.

$270,000–$290,000/yr
US Unlimited PTO

  • Design, develop, and deploy machine learning and statistical models for forecasting and risk assessment.
  • Use experimentation and statistical methods to test product changes and improve customer experience.
  • Analyze large datasets to identify signals, engineer features, and inform model design.

Pipe is a financial technology company that provides a platform for businesses to access capital. It is a fully remote company with a culture of authenticity, humility, and excellence.

$228,600–$317,500/yr
Europe

  • Define and drive the company's AI research strategy, identifying emerging technologies and translating them into a practical product roadmap.
  • Lead the development of advanced evaluation frameworks for autonomous AI agents, measuring performance across complex, non-deterministic workflows.
  • Design, prototype, and deploy innovative AI capabilities, moving rapidly from experimentation to production-ready solutions.

This company is building next-generation AI systems that solve complex real-world cybersecurity challenges at scale. The organization is a rapidly growing, venture-backed technology company with an ambitious engineering team led by experienced leaders from globally recognized technology companies.

$250,000–$265,000/yr
US Unlimited PTO 16w maternity 8w paternity

  • Design and build core architecture for AI systems spanning multiple product areas, ensuring coherence and reuse.
  • Set the technical bar for the org in evaluation frameworks, testing philosophy, CI/CD for model behavior, and shared infrastructure.
  • Take direct ownership of the hardest, most ambiguous technical problems and build solutions end-to-end.

Twin Health empowers people to prevent and reverse chronic metabolic diseases using AI Digital Twin technology. The company is rapidly scaling across the U.S. and globally with over $100 million raised, and has been recognized as an innovator and top workplace.

$120,000–$160,000/yr
US Unlimited PTO

  • Define and lead prompt framework design and strategy, including architecture, version control, and deployment for distributed teams.
  • Design complex prompt systems like multi-agent and chain-of-thought architectures for resume builder flows across global product lines.
  • Partner with Engineering, Product, and Data teams to align prompt strategies with model selection, API cost reduction, and performance budgets.

BOLD helps people find jobs through digital products used in 180 countries. As an established global organization, they have empowered millions to build stronger resumes and cover letters, with a culture that values expertise, learning, and diversity.

$258,000–$348,000/yr
United States Unlimited PTO

  • Own AI evaluation methods and operations for Figma's AI-powered experiences, defining quality dimensions and designing measurement frameworks.
  • Build and maintain evaluation frameworks, rubrics, golden datasets, and quality bars using human and automated approaches.
  • Produce clear readouts and dashboards to enable stakeholders to make confident shipping decisions.

Figma is on a mission to make design accessible to all, empowering teams to bring ideas to life through collaborative design and prototyping tools. With a growing team of passionate creatives and builders, Figma fosters a culture of growth and inclusivity.

$150,000–$250,000/yr
United States Canada South America Europe

  • Own the generative AI stack end-to-end, from discovery and scaling to maintenance.
  • Architect face consistency, model selection, and pipeline for 12+ characters.
  • Set the technical standard for the studio as it scales from 12 to 50 characters.

MindAlter Studio builds AI characters with personalities and audiences, generating revenue through social media content. The studio is a fast-moving team of obsessive owners, founded in 2024, with a culture of bias toward action and low ego.

$190,000–$230,000/yr
Global

  • Identify and design AI-powered agentic architecture to automate repetitive tasks in creative and technical workflows.
  • Define end-to-end architecture for AI frameworks, integrating with DCC tools and building reusable components.
  • Drive adoption, create documentation, and report automation impact to studio leadership.

DreamWorks Animation is a leading producer of animated films and series, known for high-quality, award-winning content. They foster a growth-minded community of artists, technologists, and innovators who value transparency, trust, and collaboration.