Remote Software engineering Jobs · Python

Job listings

  • Design and ship production AI features end-to-end across LangGraph / LiteLLM / pgvector / Langfuse.
  • Drive technical architecture for the AI product line: LLM orchestration, evals, observability, latency / cost / reliability tradeoffs.
  • Own AI initiatives technically — from spec through production, including rollout and post-launch eval improvements.

airSlate is a global SaaS technology company that develops no-code workflow automation, electronic signature, and document management solutions. They have over hundreds of millions of users and more than one million customers worldwide, helping organizations of every size digitize processes, improve efficiency, and transform how they work.

$130,000–$142,000/yr

  • Contribute designs, code, tests, code reviews, and excellent judgment towards the development and continuous improvement of our digital platforms.
  • Participate in agile ceremonies and evolving development practices of the team.
  • Provide stewardship of the long-term sustainability of our platform and actively manage platform health and technical debt.

PLOS is a nonprofit, Open Access publisher that empowers researchers to accelerate progress in science and medicine by leading a transformation in research communication. They are supported by a highly skilled global in-house team, partnerships with local scholarly organizations, and the valued contributions of a diverse, international community of scientific researchers.

US Unlimited PTO

  • Drive architecture and technical strategy for core platform systems, APIs, and data pipelines
  • Hire, manage, and develop a high-performing engineering team
  • Partner with Product and Data teams to define scope, timelines, and tradeoffs

VulnCheck is transforming exploit intelligence by helping security teams act faster. They deliver exploit intelligence, asset correlation, and contextual insights. Founded in 2021 in Lexington, Massachusetts, they have a transparent, collaborative, and supportive culture.

$125,000–$175,000/yr

  • Break down larger projects into individual tasks and deliver them in multiple phases.
  • Collaborate with product management, design & analytics by participating in ideation.
  • Contribute to a sense of community on your team by engaging in growth and development activities.

Affirm is reinventing credit to make it more honest and friendly, giving consumers the flexibility to buy now and pay later without any hidden fees or compounding interest. Affirm is a remote-first company.

$180,000–$240,000/yr

  • Be part of the alignment research team, working on projects selected for their high upside potential and under-resourced status.
  • Do real alignment research with real autonomy, in directions most organizations aren’t set up to pursue.
  • Break complex problems into concrete experiments and execute on them, independently or with a team.

AE Studio is a 160-person, fully bootstrapped ML consultancy that has spent over a decade building and shipping AI systems for clients. Without outside investors, we put money into alignment research through the AI Alignment Foundation, a nonprofit we founded to scale this work.

$135,000–$170,000/yr
US Unlimited PTO

  • Design, build, and maintain scalable backend services, APIs, and distributed systems using Python and cloud-native architectures.
  • Develop modern full-stack applications and internal platforms using React/Next.js and related frontend technologies.
  • Lead complex technical initiatives from architecture and design through implementation and deployment.

Impiricus is the first and only AI-powered HCP Engagement Engine that ethically connects HCPs to pharma resources, reduce go-to-market costs and accelerate patient access to the treatments they need. Deloitte named Impiricus the #1 fastest growing company in North America in 2025.

$116,449–$139,531/yr
Europe 6w PTO

  • Take an active role in influencing our roadmap and your own career objectives.
  • Drive projects from initial ideation all the way to operations once it is in the hands of customers.
  • Design, build, operate, and maintain critical systems, owning the reliability, performance, and availability.

Grafana Labs is behind the open observability cloud, and is founded on the principles of open source, open standards, open ecosystems, and open culture. They are a 100% remote company with 1,600+ team members across 40+ countries.

$200,000–$275,000/yr

  • Lead a high performing backend engineering team (Kotlin & Python)
  • Collaborate with Product, Analytics, Design, Operations, and other engineering teams to develop a technical roadmap that meets customer & business needs
  • Coach, develop, retain, and provide thoughtful feedback to team members

Affirm is reinventing credit to make it more honest and friendly, giving consumers the flexibility to buy now and pay later without any hidden fees or compounding interest. They are experiencing rapid growth with millions of customers across thousands of merchants in-store and online, and your contributions will be a key enabler of that growth.

US Unlimited PTO

  • Design, develop, and maintain scalable, reliable, and secure software systems that support Humata's healthcare platform
  • Build and enhance backend services, APIs, workflows, and distributed systems that process healthcare data at scale
  • Collaborate with product managers, designers, clinicians, and other engineers to deliver impactful features and improvements

Humata Health creates frictionless prior authorization for providers and payers through proprietary AI and automation technology. They are a physician-led company backed by strategic healthcare investors, focusing on improving patient care and operational efficiency in the healthcare ecosystem.

  • Design and develop modern full-stack application features using React, TypeScript, Python, and FastAPI.
  • Develop backend APIs and services that integrate with internal enterprise systems and downstream workflows.
  • Help modernize and simplify legacy operational processes through thoughtful application design and automation.

Trility Consulting fosters a strong, remote-work culture where people thrive, earning them a Great Place to Work Certification. They embrace flexible schedules and collaboration across geographically distributed teams serving clients from all corners of the United States and globally.