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$150,000–$205,000/yr
US

  • Lead project execution by aligning client needs with team tasks and deliverables.
  • Collaborate with Regulatory Affairs partners to define system intent, launch strategies, and regulatory pathways.
  • Provide real-time guidance, training, and problem-solving for engineers, particularly within the Software Test and documentation realms.

Python C++ Agile FDA

20 jobs similar to Principal System Engineer

Jobs ranked by similarity.

$147,900–$203,000/yr
US 4w PTO

  • Provide oversight for medical device software products through all phases of the development process.
  • Guide the software development team to define critical safety and performance requirements.
  • Support the timely handling of complaint investigations, change impact assessments, and CAPAs.

Oura's mission is to empower every person to own their inner potential with award-winning products that help their global community gain a deeper knowledge of their readiness, activity, and sleep quality. They have offices in San Francisco, San Diego and Los Angeles for those who prefer hybrid or office settings, and they're committed to ensuring that their team members have what they need to do their best work.

US Unlimited PTO 16w maternity

  • Lead and grow a team of the best security engineers.
  • Define the strategy for Vanta’s application security program.
  • Work with Engineering and Product Development to assess and mitigate risk.

Vanta helps businesses earn and prove trust by providing continuous security monitoring and verification. They aim to empower companies to practice better security with their automation and orchestration tools. Vanta has a kind and talented team, embracing individuals with and without prior security experience.

US

  • Serve as Lead Technical Engineer for cybersecurity assessment and authorization execution.
  • Lead implementation of RMF controls across systems, enclaves, and sites.
  • Conduct vulnerability assessments using ACAS, HBSS, and related tools.

TekSynap is a fast-growing high-tech company that understands the pace of technology and the need for a comprehensive information management environment. They utilize information technology to meet the business needs of Federal Government customers.

$176,000–$200,000/yr
US

  • Leads the architecture, design, and implementation of complex software systems.
  • Writes, reviews, and approves code using current programming languages and technologies.
  • Champions secure software development practices, ensuring solutions meet security standards.

Hanger, Inc. is the world's premier provider of orthotic and prosthetic (O&P) services and products, offering the most advanced O&P solutions, clinically differentiated programs and unsurpassed customer service. Hanger's vision is to lead the orthotic and prosthetic markets by providing superior patient care, outcomes, services and value.

$125,000–$155,000/yr

  • Responsible for managing and growing a comprehensive third-party risk management program across the organization.
  • Ensuring that Privia Health's information assets are safeguarded against cyber threats originating from third and fourth parties.
  • Leading the Third Party Access Committee (TPAC), driving compliance with regulations and implementing industry best practices for vendor risk management.

Privia Health is a technology-driven, national physician enablement company that collaborates with medical groups, health plans, and health systems to optimize physician practices, improve patient experiences, and reward doctors for delivering high-value care. The Privia Platform is led by top industry talent and exceptional physician leadership.

$190,000–$225,000/yr
US Unlimited PTO

  • Manage a diverse team of ~15 software leads, engineers, and data scientists.
  • Foster a positive and collaborative work environment.
  • Guide technical decision-making and resolve engineering tradeoffs.

MO helps government leaders shape the future by engineering scalable, human-centered solutions. Their teams blend product, design, AI, data, and modern software practices to modernize legacy systems and build new digital platforms, employing technologists, designers, and builders.

$201,450–$286,650/yr
US

  • Partner with Regulatory Affairs and Quality Assurance teams to create software validation processes.
  • Coordinate software testing efforts within and across teams.
  • Support recruitment, technical staffing, and organizational design to grow the testing team.

Freenome is a company focused on early cancer detection through innovative diagnostic products that leverage their engineering software platform. They are a high-profile tech organization experiencing rapid growth, valuing diversity, and committed to equal opportunity.

$229,000–$366,000/yr
US

  • Support the Lead Solution Architect in the development of compliant, compelling and executable solutions.
  • Work closely with Business Development, Capture Manager, and Corporate Offerings teams to determine the overall solution strategy.
  • Support the development of solutions presented during governance reviews with senior Peraton management.

Peraton is a next-generation national security company that drives missions of consequence spanning the globe. As the world’s leading mission capability integrator and transformative enterprise IT provider, they deliver trusted, highly differentiated solutions.

$146,000–$234,000/yr
US

  • Own all cybersecurity operations for assigned workstream: SIEM/EDR, identity and access management, vulnerability remediation, patching, and security monitoring.
  • Manage ATO packages and lead system accreditation efforts across mission and enterprise systems, ensuring compliance with RMF, FISMA, and customer-specific controls.
  • Ensure CMS modernization efforts incorporate required cyber controls, audit readiness, and DCSA/DHS security expectations.

Peraton is a next-generation national security company that drives missions of consequence spanning the globe. As a mission capability integrator and transformative enterprise IT provider, they deliver trusted, highly differentiated solutions and technologies to protect our nation and allies.

$250,000–$275,000/yr
US Unlimited PTO 2w maternity 2w paternity

  • Lead and support multiple engineering teams, lead very senior engineers, ensuring consistent delivery, strong technical quality, and healthy team operations.
  • Define and guide technical architecture and long-term system strategy across the teams within your scope and in collaboration with EMEA engineering leadership.
  • Own and manage technical roadmaps jointly with the VP of Product, VP of Engineering and Director of Engineering in EMEA.

CoderPad is on a mission to fix the technical interview process. We serve over 3,800 customers and have hosted more than 4 million technical interviews in 90+ programming languages since our launch in 2013 and it has become a leading interview platform.

US

  • Leads the design and engineering of complex IT systems.
  • Produces solution architectures that are secure and scalable.
  • Coordinates with stakeholders and vendors throughout project execution.

DMI is a leading provider of digital services and technology solutions. They focus on end-to-end managed IT services and support public sector agencies and commercial enterprises around the globe.

US

  • Support safety and reliability of autonomous robotic vehicles.
  • Perform hazard/risk analysis (STPA), define safety requirements, and ensure compliance across product lifecycle.
  • Collaborate with cross-functional teams to integrate safety into design, development, verification, and validation.

The job posting is for a Functional Safety Engineer role at Google, which suggests they're involved in innovative technology. The job description does not provide information about the company's size, employee count, or culture.

Europe

  • Develop and execute an enterprise-wide security strategy aligned to FMCG priorities and digital transformation.
  • Provide senior leadership and board-level guidance on threats, risks, and regulatory impacts.
  • Lead cybersecurity, data protection, and OT security initiatives.

ICIMS is a software company. They provide talent acquisition solutions to businesses.

US

  • Manage the full lifecycle of application and system projects from intake through delivery using SAFe DevSecOps frameworks.
  • Lead Agile Scrum teams, ensuring alignment across products, deliverables, and project timelines.
  • Coordinate across teams and stakeholders to manage dependencies, risks, and competing priorities.

VetsEZ is dedicated to supporting government agencies with transformative IT solutions. While the employee count is not specified, they foster innovation, collaboration, and a commitment to excellence.

$145,000–$180,000/yr
US

  • Deliver coordinated, accurate, and well-documented work on time and within budget.
  • Identify risks early and maintain project momentum.
  • Mentor engineers and production team members by providing technical guidance.

TEECOM delivers complex, multi-discipline projects as a trusted subject matter expert. They seem to have a modern, team-oriented culture, as they focus on best practices, collaboration, and mentorship to improve project outcomes and support employee growth.

$205,900–$289,600/yr
Canada EMEA US Unlimited PTO

  • Lead, develop, and mentor a team of Product Security Architects.
  • Own and continuously evolve the Product Security Architecture strategy.
  • Oversee and mature the Product Security Risk Register.

GitLab is the intelligent orchestration platform for DevSecOps. They enable organizations to increase developer productivity, improve operational efficiency, reduce security and compliance risk, and accelerate digital transformation. They have more than 50 million registered users and they value high-performance culture is driven by values and continuous knowledge exchange.

US

  • Design, implement, and sustain security architecture across AWS GovCloud.
  • Execute and maintain RMF activities across all system components.
  • Implement, validate, and continuously maintain DISA STIG compliance across all infrastructure components.

Foxhole Technology provides robust cybersecurity and IT support capabilities for federal civilian and defense agencies. A recognized leader in navigating technology and security challenges, Foxhole delivers mission-focused innovations to answer evolving and complex needs.

US

  • Apply compliance frameworks to assess, design, and implement security controls.
  • Conduct compliance gap assessments and develop remediation plans.
  • Create and maintain key documentation tailored to client needs.

AHEAD builds platforms for digital business by weaving together advances in cloud infrastructure, automation and analytics, and software delivery. They prioritize creating a culture of belonging where all perspectives and voices are represented, valued, respected, and heard.

$170,000–$210,000/yr
3w PTO

  • Serve as the technical lead on enterprise client engagements.
  • Architect, build, and maintain microservice-based systems.
  • Mentor individual contributors through code reviews and technical coaching.

Effectual is a cloud-native and modernization services company. We help organizations transform and modernize their systems using leading-edge technologies. We are an EEO employer.

Global

  • Accelerate Onebrief’s execution of GRC programs supporting NIST RMF, FedRAMP High, CMMC, and SOC2 authorizations
  • Develop and manage integrated project plans for control implementation, remediation, and continuous monitoring
  • Coordinate cross-functional teams (Infrastructure, Engineering, Product) to ensure timely delivery of compliance requirements

Onebrief provides collaboration and AI-powered workflow software designed specifically for military staffs, aiming to make them faster, smarter, and more efficient. Valued at $2.15B, the company has raised $320m+ from top-tier investors and operates as an all-remote company.